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1

A status report on RNAi therapeutics

Akshay K Vaishnaw, Jared Gollob, Christina Gamba-Vitalo, Renta Hutabarat, Dinah Sah, Rachel Meyers, Tony de Fougerolles, John Maraganore

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1011 KB

english, 2010

2

Interfering with disease: a progress report on siRNA-based therapeutics

de Fougerolles, Antonin, Vornlocher, Hans-Peter, Maraganore, John, Lieberman, Judy

Journal:

Nature Reviews Drug Discovery

Année:

2007

Langue:

english

Fichier:

PDF, 427 KB

english, 2007

3

US immigration order strikes against biotech

Levin, Jeremy M, Holtzman, Steven H, Maraganore, John, Hastings, Paul J, Cohen, Ron, Dahiyat, Bassil, Adams, Julian, Adams, Chris, Ahrens, Brett, Albers, Jeff, Aspinall, Mara G, Audia, James E, Babler

Journal:

Nature Biotechnology

Année:

2017

Langue:

english

Fichier:

PDF, 133 KB

english, 2017

4

Kinetic Mechanism for the Interaction of Hirulog with Thrombin

Parry, Marina A. A., Maraganore, John M., Stone, Stuart R.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 934 KB

english, 1994

5

Table of Contents

Lesnick, Timothy G., Papapetropoulos, Spiridon, Mash, Deborah C., Ffrench-Mullen, Jarlath, Shehadeh, Lina, de Andrade, Mariza, Henley, John R., Rocca, Walter A., Ahlskog, J. Eric, Maraganore, Demetriu

Journal:

IEEE Transactions on Power Electronics

Année:

2010

Langue:

english

Fichier:

PDF, 46 KB

english, 2010

6

First rounders: John Maraganore

Maraganore, John

Journal:

Nature Biotechnology

Année:

2018

Langue:

english

Fichier:

PDF, 99 KB

english, 2018

7

Biotech leaders call for free press

Cohen, Ron, Holtzman, Steven, Levin, Jeremy M, Maraganore, John M, Aberman, Michael, Adams, Chris, Adams, Julian, Albers, Jeffrey, Anderson, Bonnie, Aspinall, Mara G, Audia, James E, Babler, Martin, B

Journal:

Nature Biotechnology

Année:

2018

Langue:

english

Fichier:

PDF, 130 KB

english, 2018

8

Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with lewy body parkinsonism

Hardy, John, P�rez-Tur, Jordi, Baker, Matt, Farrer, Matt, Crook, Richard, Hutton, Mike, Johnson, William G., Gwinn, Katrina, Muenter, Manfred, Rocca, Walter A., Maraganore, Demetrius

Journal:

American Journal of Medical Genetics

Année:

1998

Langue:

english

Fichier:

PDF, 122 KB

english, 1998

9

Case-control study of debrisoquine 4-hydroxylase, n-acetyltransferase 2, and apolipoprotein e gene polymorphisms in Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, John A. Hardy, Shannon K. McDonnell, Daniel J. Schaid, Walter A. Rocca

Journal:

Movement Disorders

Année:

2000

Langue:

english

Fichier:

PDF, 54 KB

english, 2000

10

Case-control study of the extended tau gene haplotype in Parkinson's disease

Demetrius M. Maraganore, Dena G. Hernandez, Andrew B. Singleton, Matthew J. Farrer, Shannon K. McDonnell, Michael L. Hutton, John A. Hardy, Walter A. Rocca

Journal:

Annals of Neurology

Année:

2001

Langue:

english

Fichier:

PDF, 12.19 MB

english, 2001

11

Low frequency of α-synuclein mutations in familial Parkinson's disease

Matt Farrer, Fabienne Wavrant-De Vrieze, Richard Crook, Lizzie Boles, Jordi Perez-Tur, John Hardy, William G. Johnson, John Steele, Demetrius Maraganore, Dr Katrina Gwinn, Tim Lynch

Journal:

Annals of Neurology

Année:

1998

Langue:

english

Fichier:

PDF, 404 KB

english, 1998

12

Case-Control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease

John L. Goudreau, Demetrius M. Maraganore, Matthew J. Farrer, Timothy G. Lesnick, Andrew B. Singleton, James H. Bower, John A. Hardy, Walter A. Rocca

Journal:

Movement Disorders

Année:

2002

Langue:

english

Fichier:

PDF, 73 KB

english, 2002

13

Complex interactions in Parkinson's disease: A two-phased approach

Demetrius M. Maraganore, Mariza de Andrade, Timothy G. Lesnick, Matthew J. Farrer, James H. Bower, John A. Hardy, Walter A. Rocca

Journal:

Movement Disorders

Année:

2003

Langue:

english

Fichier:

PDF, 78 KB

english, 2003

14

Case-control study of the α-synuclein interacting protein gene and Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, Timothy G. Lesnick, Mariza De Andrade, James H. Bower, Dena Hernandez, John A. Hardy, Walter A. Rocca

Journal:

Movement Disorders

Année:

2003

Langue:

english

Fichier:

PDF, 71 KB

english, 2003

15

Parkin variants in North American Parkinson's disease: Cases and controls

Sarah J. Lincoln, Demetrius M. Maraganore, Timothy G. Lesnick, Rebecca Bounds, Mariza de Andrade, James H. Bower, John A. Hardy, Matthew J. Farrer

Journal:

Movement Disorders

Année:

2003

Langue:

english

Fichier:

PDF, 69 KB

english, 2003

16

International Medical Workshop covering progressive supranuclear palsy, multiple system atrophy and cortico basal degeneration

Dennis W. Dickson, Brian Anderton, Huw Morris, John Hodges, Thomas H Bak, B. Dubois, B. Pillon, T. Bak, R. Rafal, J. Grafman, Lawrence I. Golbe, John Steele, Demetrius M. Maraganore, Marie Vidailhet,

Journal:

Movement Disorders

Année:

2001

Langue:

english

Fichier:

PDF, 79 KB

english, 2001

17

Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, Shannon K. McDonnell, Alexis Elbaz, Daniel J. Schaid, John A. Hardy, Walter A. Rocca

Journal:

Movement Disorders

Année:

2002

Langue:

english

Fichier:

PDF, 30 KB

english, 2002

18

Hirudin and Hirulog: Advances in antithrombotic therapy

John M. Maraganore

Journal:

Perspectives in Drug Discovery and Design

Année:

1994

Langue:

english

Fichier:

PDF, 1.82 MB

english, 1994

19

Heparin resistance in acute coronary syndromes

Jonathan D. Rich, John M. Maraganore, Edward Young, Rosa-Maria Lidon, Burt Adelman, Paul Bourdon, Supoat Charenkavanich, Jack Hirsh, Pierre Theroux, Christopher P. Cannon

Journal:

Journal of Thrombosis and Thrombolysis

Année:

2007

Langue:

english

Fichier:

PDF, 189 KB

english, 2007

20

The house that George built

Maraganore, John

Journal:

Nature Biotechnology

Année:

2009

Langue:

english

Fichier:

PDF, 105 KB

english, 2009

21

Systemic Thrombin Inhibition by Hirulog Does Not Alter Medial Smooth Muscle Cell Proliferation and Inflammatory Activation after Vascular Injury in the Rabbit

Roger Kranzhöfer, John M. Maraganore, Rem Baciu, Peter Libby

Journal:

Cardiovascular Drugs and Therapy

Année:

1999

Langue:

english

Fichier:

PDF, 284 KB

english, 1999

22

Phospholipases A2: Variations on a structural theme and their implications as to mechanism

John M. Maraganore, Roger A. Poorman, Robert L. Heinrikson

Journal:

The Protein Journal

Année:

1987

Langue:

english

Fichier:

PDF, 933 KB

english, 1987

23

Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery disease

Christopher P. Cannon, John M. Maraganore, Joseph Loscalzo, Arthur McAllister, Karen Eddings, Dorinda George, Andrew P. Selwyn, Burt Adelman, Irving Fox, Eugene Braunwald, Peter Ganz

Journal:

The American Journal of Cardiology

Année:

1993

Langue:

english

Fichier:

PDF, 685 KB

english, 1993

24

Relation between binding and the action of phospholipases A2 on Escherichia coli exposed to the bactericidal/permeability-increasing protein of neutrophils

Steven Forst, Jerrold Weiss, John M. Maraganore, Robert L. Heinrikson, Peter Elsbach

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Année:

1987

Langue:

english

Fichier:

PDF, 495 KB

english, 1987

25

The role of lysyl residues of phospholipases A2 in the formation of the catalytic complex

John M. Maraganore, Robert L. Heinrikson

Journal:

Biochemical and Biophysical Research Communications

Année:

1985

Langue:

english

Fichier:

PDF, 434 KB

english, 1985

26

Hirulog peptides with scissile bond replacements resistant to thrombin cleavage

Toni Kline, Charles Hammond, Paul Bourdon, John M. Maraganore

Journal:

Biochemical and Biophysical Research Communications

Année:

1991

Langue:

english

Fichier:

PDF, 445 KB

english, 1991

27

Comparison of enzymatic and pharmacological activities of lysine-49 and aspartate-49 phospholipases A2 from Agkistrodon piscivorus piscivorus snake venom

Daljit S. Dhillon, Eleonora Condrea, John M. Maraganore, Robert L. Heinrikson, Sheila Benjamin, Philip Rosenberg

Journal:

Biochemical Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 877 KB

english, 1987

28

Structure-function relationships of hirulog peptide interactions with thrombin

Paul Bourdon, Jo-Ann Jablonski, Betty H. Chao, John M. Maraganore

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 368 KB

english, 1991

29

Structure of the hirugen and hirulog 1 complexes of α-thrombin

Ewa Skrzypczak-Jankun, Vasili E. Carperos, K.G. Ravichandran, Alexander Tulinsky, Mary Westbrook, John M. Maraganore

Journal:

Journal of Molecular Biology

Année:

1991

Langue:

english

Fichier:

PDF, 1.59 MB

english, 1991

30

Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease

Manu Sharma, Demetrius M. Maraganore, John P.A. Ioannidis, Olaf Riess, Jan O. Aasly, Grazia Annesi, Nadine Abahuni, Anna Rita Bentivoglio, Alexis Brice, Christine Van Broeckhoven, Marie-Christine Char

Journal:

Neurobiology of Aging

Année:

2011

Langue:

english

Fichier:

PDF, 376 KB

english, 2011

31

A rapid method for the purification of monomeric and/or dimeric phospholipases A2 in crotalid snake venoms

William Welches, Dean Felsher, William Landshulz, John M. Maraganore

Journal:

Année:

1985

Langue:

english

Fichier:

PDF, 466 KB

english, 1985

32

Characterization of the structure and function of three phospholipases A2 from the venom of Agkistrodon halys pallas

Yuan-Chung Chen, John M. Maraganore, Ilene Reardon, Robert L. Heinrikson

Journal:

Année:

1987

Langue:

english

Fichier:

PDF, 622 KB

english, 1987

33

903-9 Effectiveness of Recombinant Hirulog® in Reducing Restenosis After Balloon Angioplasty in the Atherosclerotic Rabbit

Leonard M. Thome, S. David Gertz, Lawrence W. Gimple, Kyle W. McCoy, Eric R. Powers, John M. Maraganore, Ian J. Sarembock

Journal:

Journal of the American College of Cardiology

Année:

1995

Langue:

english

Fichier:

PDF, 280 KB

english, 1995

34

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors

Qiu, Xiayang, Padmanabhan, Kanagapushpam P., Carperos, Vasili E., Tulinsky, Alexander, Kline, Toni, Maraganore, John M., Fenton, John W.

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.89 MB

english, 1992

35

Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor

Chao, Betty H., Kalkunte, Sandhya, Maraganore, John M., Stone, Stuart R.

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 486 KB

english, 1992

36

The Incidence and Prevalence of Myoclonus in Olmsted County, Minnesota

Caviness, John N., Alving, Loren I., Maraganore, Demetrius M., Black, Rita A., Mcdonnell, Shannon K., Rocca, Walter A.

Journal:

Mayo Clinic Proceedings

Année:

1999

Langue:

english

Fichier:

PDF, 4.72 MB

english, 1999

37

Structural elements for protein-phospholipid interactions may be shared in protein kinase C and phospholipases A2

Maraganore, John M.

Journal:

Trends in Biochemical Sciences

Année:

1987

Langue:

english

Fichier:

PDF, 192 KB

english, 1987

38

Which class of serine is involved in the lipase mechanism?

Maraganore, John M., Heinrikson, Robert L.

Journal:

Trends in Biochemical Sciences

Année:

1986

Langue:

english

Fichier:

PDF, 193 KB

english, 1986

39

Agkistrodon piscivorus piscivorus Platelet Aggregation Inhibitor: A Potent Inhibitor of Platelet Activation

Betty H. Chao, Joseph A. Jakubowski, Brian Savage, E. Ping Chow, Ulla M. Marzec, Laurence A. Harker and John M. Maraganore

Journal:

Proceedings of the National Academy of Sciences

Année:

1989

Langue:

english

Fichier:

PDF, 1.29 MB

english, 1989

40

Technology: Investment suggests RNAi is on the up

Maraganore, John

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 762 KB

english, 2014

41

Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate

Forst, Steven, Weiss, Jerrold, Elsbach, Peter, Maraganore, John M., Reardon, Ilene, Heinrikson, Robert L.

Journal:

Année:

1986

Langue:

english

Fichier:

PDF, 624 KB

english, 1986

42

Affinity labeling of lysine-149 in the anion-binding exosite of human .alpha.-thrombin with an N.alpha.-(dinitrofluorobenzyl)hirudin C-terminal peptide

Bourdon, Paul, Fenton, John W., Maraganore, John M.

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 2.38 MB

english, 1990

43

Treatment with Bivalirudin (Hirulog) as Compared with Heparin during Coronary Angioplasty for Unstable or Postinfarction Angina

Bittl, John A., Strony, John, Brinker, Jeffrey A., Ahmed, Waqar H., Meckel, Clyde R., Chaitman, Bernard R., Maraganore, John, Deutsch, Ezra, Adelman, Burt

Journal:

Boston Medical and Surgical Journal

Année:

1995

Langue:

english

Fichier:

PDF, 120 KB

english, 1995

44

Antithrombotic Effects of Synthetic Peptides Targeting Various Functional Domains of Thrombin

Andrew B. Kelly, John M. Maraganore, Paul Bourdon, Stephen R. Hanson and Laurence A. Harker

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1013 KB

english, 1992

45

A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease

Lesnick, Timothy G., Papapetropoulos, Spiridon, Mash, Deborah C., Ffrench-Mullen, Jarlath, Shehadeh, Lina, de Andrade, Mariza, Henley, John R., Rocca, Walter A., Ahlskog, J. Eric, Maraganore, Demetriu

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 386 KB

english, 2007

46

Selective Inhibition by a Synthetic Hirudin Peptide of Fibrin-Dependent Thrombosis in Baboons

Yves Cadroy, John M. Maraganore, Stephen R. Hanson and Laurence A. Harker

Journal:

Proceedings of the National Academy of Sciences

Année:

1991

Langue:

english

Fichier:

PDF, 971 KB

english, 1991

47

Hirulog

John, M. Maraganore, Burt, A. Adelman

Journal:

Coronary Artery Disease

Année:

1996

Fichier:

PDF, 755 KB

1996

48

Effectiveness of Hirulog in Reducing Restenosis after Balloon Angioplasty of Atherosclerotic Femoral Arteries in Rabbits

Sarembock, Ian J., Gertz, David, Thome, Leonard M., McCoy, Kyle W., Ragosta, Michael, Powers, Eric R., Maraganore, John M., Gimple, Lawrence W.

Journal:

Journal of Vascular Research

Année:

1996

Langue:

english

Fichier:

PDF, 1.32 MB

english, 1996

49

Beyond Parkinson Disease: Amyotrophic Lateral Sclerosis and the Axon Guidance Pathway

Lesnick, Timothy G., Sorenson, Eric J., Ahlskog, J. Eric, Henley, John R., Shehadeh, Lina, Papapetropoulos, Spiridon, Maraganore, Demetrius M., Callaerts, Patrick

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 288 KB

english, 2008

50

Proposals to Lower Medication Costs

Cohen, Ron, Levin, Jeremy M., Maraganore, John M.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 68 KB

english, 2019